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Fatigue Causes

Sleep disturbances

Not enough sleep

Too much sleep

Sleep apnea

Shift work (changing shifts, night shifts)

Alcohol

Heart diseases

Congestive heart failure (fluid in lungs)

Cardiomyopathy (dysfunction of the heart muscle)

Lung diseases

Asthma

Emphysema or chronic obstructive pulmonary disease (COPD)

Pneumonia

Nutritional disorders

Malnutrition (kwashiorkor, protein deficiency or marasmus, total calorie deficiency)

Obesity

Vitamin deficiency (thiamine, B12, B6, folate, vitamin C)

Electrolyte disturbances

Low potassium

Low magnesium

Low or high calcium

Low sodium


Endocrine disorders

Low blood sugar or high blood sugar (diabetes)

High or low thyroid

Low cortisol (Addison disease)

High cortisol (Cushing disease)

Gastrointestinal disorders

Gastroesophageal reflux disease (GERD)

Peptic ulcer disease (PUD)

Neurological disorders

Multiple sclerosis

Stroke

Lou Gehrig disease

Infectious causes

Any chronic disease

HIV/AIDS

Tuberculosis

Hepatitis

Mononucleosis

Chronic fatigue syndrome

Urinary tract infections

Connective tissue disorders

Arthritis (osteoarthritis and rheumatoid arthritis)

Lupus (SLE)

Fibromyalgia

Acromegaly

General disorders

Cancer

Anemia (blood loss or not making enough blood)

Gynecologic

Pregnancy

Menopause

Exercise disturbances

Lack of exercise

Too much exercise (worn out)

Excessive workload

Psychological

Depression (loss of interest, ambition)

Anxiety

Grief

Stress

Blood pressure medications work by different mechanisms to decrease blood pressure. The ultimate decrease in blood pressure also means a decrease in the amount of work the heart is doing, which can lead to a feeling of fatigue. Sometimes, the drug works not only on the heart, but also on the central nervous system.

Beta-blockers

Calcium channel blockers

Diuretics

ACE inhibitors

Heart medications work in different ways to regulate the heartbeat. Fatigue can be related to the effects the medication has on the heart or to the effects that spill over to other areas of the body.

Digoxin (Lanoxin)

Amiodarone (Cordarone, Pacerone)

Procainamide (Promine, Rhythmin)

Psychological medications used to help depression and anxiety work by increasing neurotransmitters in the brain that have a calming effect on the body, thus stimulating fatigue.

Antidepressants

Antipsychotics

Antianxiety medications (such as diazepam [Valium] or zolpidem [Ambien])

Narcotics: Many pain medications are opiate derived. Drowsiness can be caused by opiates.

Acetaminophen and codeine (Tylenol with Codeine)

Hydrocodone and acetaminophen (Vicodin)

Oxycodone and acetaminophen (Percocet)

Propoxyphene and acetaminophen (Darvocet)

Muscle relaxants work to decrease the contraction of muscles. This relaxation can lead to total body relaxation, which may cause you to feel fatigued.

Cyclobenzaprine (Flexeril)

Carisoprodol (Soma)

Orphenadrine (Norflex)


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