Not enough sleep
Too much sleep
Shift work (changing shifts, night shifts)
Congestive heart failure (fluid in lungs)
Cardiomyopathy (dysfunction of the heart muscle)
Emphysema or chronic obstructive pulmonary disease (COPD)
Malnutrition (kwashiorkor, protein deficiency or marasmus, total calorie deficiency)
Vitamin deficiency (thiamine, B12, B6, folate, vitamin C)
Low or high calcium
Low blood sugar or high blood sugar (diabetes)
High or low thyroid
Low cortisol (
High cortisol (Cushing disease)
Gastroesophageal reflux disease (GERD)
Peptic ulcer disease (PUD)
Lou Gehrig disease
Any chronic disease
Chronic fatigue syndrome
Urinary tract infections
Connective tissue disorders
Arthritis (osteoarthritis and rheumatoid arthritis)
Anemia (blood loss or not making enough blood)
Lack of exercise
Too much exercise (worn out)
Depression (loss of interest, ambition)
Blood pressure medications work by different mechanisms to decrease blood pressure. The ultimate decrease in blood pressure also means a decrease in the amount of work the heart is doing, which can lead to a feeling of fatigue. Sometimes, the drug works not only on the heart, but also on the central nervous system.
Calcium channel blockers
Heart medications work in different ways to regulate the heartbeat. Fatigue can be related to the effects the medication has on the heart or to the effects that spill over to other areas of the body.
Amiodarone (Cordarone, Pacerone)
Procainamide (Promine, Rhythmin)
Psychological medications used to help depression and anxiety work by increasing neurotransmitters in the brain that have a calming effect on the body, thus stimulating fatigue.
Antianxiety medications (such as diazepam [Valium] or zolpidem [Ambien])
Narcotics: Many pain medications are opiate derived. Drowsiness can be caused by opiates.
Acetaminophen and codeine (Tylenol with Codeine)
Hydrocodone and acetaminophen (Vicodin)
Oxycodone and acetaminophen (Percocet)
Propoxyphene and acetaminophen (Darvocet)
Muscle relaxants work to decrease the contraction of muscles. This relaxation can lead to total body relaxation, which may cause you to feel fatigued.